AstraZeneca GmbH

Job Title: Translational Science Lead Location: Cambridge Salary: Competitive Introduction to the role Are you ready to turn human biology into decisive clinical evidence that advances medicines for people living with respiratory disease? Based in Cambridge, you will lead end to end translational strategies that move confident science into the clinic, fast. Your work will connect target selection to first in human studies and beyond, delivering the mechanistic clarity, patient stratification and biomarker evidence that shape smart decisions and successful development. In this role, you will partner across discovery and clinical teams to validate human targets, define and implement target engagement and PoM biomarkers, and integrate multi omics and clinical data into actionable insights. Do you thrive at the interface of experimental biology, precision medicine and clinical execution, where a well designed biomarker plan can change the trajectory of a programme and the lives of patients? Accountabilities Develop and integrate translational strategies for respiratory projects and clinical studies, spanning human target validation, target engagement and precision medicine to de risk decisions and accelerate progress. Build robust human validation plans at target selection, partnering with bioscience teams and leveraging public and proprietary biobanks to identify responding subpopulations and strengthen biological rationale. Design and lead innovative experimental approaches to deepen understanding of disease pathways and target biology, selecting the right technologies to answer pivotal questions. Define, invent and enable PoM biomarkers; establish target engagement assays; plan and execute biomarker sampling strategies; and drive assay transfer and execution in clinical trials. Deliver precision medicine strategies to identify the patients most likely to benefit, including early planning for molecular assays when clinical features alone are insufficient. Integrate clinical, biomarker and multi omics data; partner with data science teams to apply AI/ML to uncover mechanisms, biomarkers and patient phenotypes that inform study design and readouts. Establish and lead external collaborations and patient cohorts to enhance disease understanding and identify clinically meaningful biomarkers. Embed translational strategy into Clinical Study Protocols, Informed Consent Forms, Sample Life Cycle Plans, Case Report Forms, local Health Authority applications, Human Genetic Resources and Clinical Study Reports. Contribute to regulatory and health authority responses; author submission sections on mechanism of action, PK/PD and precision medicine; prepare and review scientific publications to support development and launch. Represent translational strategy in governance and investment forums; drive clear cross functional communication to enable accurate, timely execution. Serve as the key scientific voice on project teams as programmes advance, generating the mechanistic differentiation and scientific evidence that support product development, launch and lifecycle opportunities. Essential Skills / Experience PhD or MD equivalent with a strong experimental drive and background in Respiratory field Post doc experience or otherwise relevant scientific research experience Strong previous experience in a Biomedical or Pharmaceutical role Strong publication record Proven ability to deliver translational readouts and human target validation and their application to drug discovery Excellent understanding of the Respiratory therapy area including but not limited to COPD, Asthma, NCFBE and IPF, and disease biology, including related molecular pathways and mechanisms Experience and knowledge of the biological basis for target engagement biomarkers and familiar with PoM biomarker invention and implementation Experience and knowledge of the biological basis for patient stratification and precision medicine, and familiar with patient selection biomarker invention and implementation Broad understanding of relevant technologies and methodologies along with excellent scientific skills and ability to design experiments to address key scientific questions Excellent skills in hypothesis forming and testing and able to draw conclusions and suggest next steps based on the experimental data Shown experience and solid understanding of pharmacology, translational medicine and clinical sciences as well as clinical development with pre eminence in at least one of these areas Demonstrated leadership skills, ability to be a self starter Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects Excellent written, oral, presentation and interpersonal skills Desirable Skills / Experience Experience leading projects Experience from clinical trials Why AstraZeneca Join a research driven organisation where bold ideas translate into real clinical impact for patients worldwide. Here, translational science sits at the heart of decision making, with unexpected teams in the same room turning complex biology, digital technologies and AI driven insights into decisive, patient focused plans. You will be trusted to follow the science, supported by collaborators across discovery, clinical and data disciplines, and empowered to test hypotheses quickly, learn from setbacks and push breakthroughs forward. We value kindness alongside ambition, and we unite academic partners, biotechs and industry experts to create the fastest path to meaningful medicines. What is next! If you are ready to lead the science that shapes smarter trials and better outcomes for people with respiratory disease, bring your translational vision to Cambridge and help turn bold biology into life changing medicines today! We are looking forward to your application not later than 26th July Date posted: 20 Jul 2026 Closing date: 26 Jul 2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca Cambridge is seeking a Translational Science Lead to drive end-to-end translational strategies that move human biology into the clinic, from target validation to first in human studies and beyond. You will partner with discovery and clinical teams to validate targets, define PoM biomarkers, and integrate multi omics data into actionable insights that shape development decisions for respiratory programmes. Collaborative culture and scientific excellence are valued.

Senior Director, Data and Information Marketplace We're building a connected, end-to-end Enterprise AI engine - uniting data foundations, AI technology, process reinvention, and business-facing AI to accelerate results across the whole value chain. Success depends on being exceptional connectors: you'll actively harness existing capabilities, celebrate and promote reuse, export breakthrough ideas across geographies and functions, and obsess over scaling impact rather than building in isolation. If you thrive in high collaboration environments where your role is to turn sophisticated, cross functional problems into reusable, enterprise wide capabilities - and where the measure of success is adoption and scale, not just innovation - you'll have the platform (and sponsorship) to make it real! Introduction to role The Senior Director, Data and Information Marketplace provides strategic leadership for the capabilities, products and governance needed to help humans and intelligent agents discover, share, understand and use data and information quickly, easily and compliantly. This role shapes an integrated Data & Information Marketplace that improves the consumption experience across the enterprise, increases confidence in data and information assets, and ensures they are accessible, transparent, governed and valuable throughout their lifecycle. It ensures that data and information can be used with trust and efficiency, supports responsible and scalable reuse, and drives adoption of product based capabilities and tooling that enhance enterprise productivity, compliance and decision making. Accountabilities Lead the vision for a unified Data & Information Marketplace that transforms how data and information are discovered, accessed and reused across the organisation. Define a clear strategy and roadmap that aligns marketplace outcomes with enterprise data, AI and business priorities, setting measurable goals and operating models that drive impact. Oversee product ownership for marketplace capabilities and tooling, ensuring intuitive experiences for both people and agents across discovery, access, sharing, understanding and use. Advise the development of capabilities for data access, lineage, observability and quality so that data assets are transparent, trusted and usable at scale. Shape enterprise approaches to data, information and knowledge lifecycle management, embedding governance for retention, stewardship, reuse, archival and disposal to maximise value while maintaining compliance. Champion new ways of managing unstructured information to improve discoverability, control and responsible use beyond traditional structured domains. Embed robust governance and control frameworks across marketplace services, aligned with legal, privacy, security and risk standards. Drive financial transparency and optimisation for marketplace platforms and services through FinOps practices that improve cost visibility, value realisation and sustainable scaling. Influence senior leaders across business, data, digital, security and compliance functions to secure adoption, prioritisation and continuous improvement of marketplace capabilities and ways of working. Ready to shape how data powers digital healthcare? Essential Skills/Experience 10+ years enterprise level leadership experience in data governance, data management, information management or enterprise data platforms, with accountability for global strategy and delivery. Experience in user experience design and evidence of translating this into easy, coherent, seamless experiences that are widely adopted by users and machines across multiple enterprise business units. Deep expertise in relevant capability areas, including data quality, observability, lineage, access management, lifecycle management and information governance. Measurable evidence of optimising the data P&L across covering cost/FinOps, value realisation and sustainability. Proven experience in product management and product ownership for enterprise data or information capabilities, including tooling, user experience and adoption at scale. Innovates, experiments and brings external perspectives, with a track record of applying frontier technologies and approaches to increase speed, quality and compliance of data. Strong collaboration skills and evidence of success in an enterprise scale federated ownership and delivery model, recognising when to build on the work and skills of others, and when to do themselves. Demonstrated ability to lead through complexity and influence senior partners across functions, driving enterprise alignment, decisions and enterprise change in a global environment. Strong communication, strategic planning and execution skills, with a track record of defining measurable outcomes, prioritising investments and delivering business value through data and information capabilities. Desirable Skills/Experience Experience leading large scale data marketplaces or catalogues in highly regulated industries. Background in applying AI/ML to metadata management, knowledge graphs or intelligent search. Track record of building data products that directly enable scientific or clinical decision making. Familiarity with cloud native architectures, modern data platforms and automation for data operations. Evidence of building high performing global teams that blend engineering, product and governance skills. When we put unexpected teams in the same room, we unleash ambitious thinking with the power to inspire life changing medicines. In person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our outstanding and ambitious world! AstraZeneca offers the chance to combine technology leadership with meaningful impact: work with modern platforms in data, analytics, AI and machine learning; experiment with innovative approaches through hackathons and modern engineering practices; collaborate with diverse experts across science and technology; and help transform how medicines are discovered, developed and delivered with strong backing, investment and a culture that encourages ownership, curiosity and continuous learning! Date Posted: 17-Jun-2026 Closing Date: 24-Jun-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca GmbH is looking for a Senior Director for Data and Information Marketplace in Cambridge, UK. This role involves providing strategic leadership for integrated data capabilities to enhance enterprise productivity. The ideal candidate will possess over 10 years of experience in data governance and management, with a focus on optimizing data usage across the organization. This role emphasizes the importance of collaboration and innovative problem-solving to propel data-driven decision-making. Join us in our mission to leverage data to transform healthcare and deliver meaningful impact.

Director, Enterprise Technology Services (ETS) Software Asset Management Location: Macclesfield UK Salary: Competitive + Excellent Benefits AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity. The AstraZeneca IT function has undergone significant transformation to improve performance and perception of IT and is now focusing on being digital to deliver business value, alongside delivering a great experience and overall service excellence as part of our IT Strategy. AstraZeneca's Workplace & Enterprise Services (WES) function is committed to delivering excellent service and technologies to ensure our IT services meet current and future business needs. The Service Asset & Configuration Management (SACM) function within Workplace & Enterprise Services is accountable for Hardware and Software Asset and Lifecycle Management and the Configuration Management Database that underpins IT Service Management for AstraZeneca. The Software Asset Management Director is the global leader of AstraZeneca's Software Asset Management (SAM) capability. The role is accountable for the strategy, policy, processes, controls, tooling and team that govern AstraZeneca's software estate - from request and procurement, through entitlement, deployment and usage, to true up and retirement. The role ensures that AstraZeneca remains license compliant, audit ready and is consistently extracting maximum value from its enterprise software investments. Reporting to the Director, Service Asset, Configuration Management (SACM), this role works within a globally distributed team (UK and the Global Technology Centre, Chennai), partners with Procurement, Legal, Cyber Security, Enterprise Architecture and the Business aligned Technology Groups (BTGs), and represents AstraZeneca with strategic software publishers and SAM tooling partners. Typical Accountabilities Strategy, governance and compliance Ownership and accountability for global Software Asset Management - strategy, policy, processes, standards, governance, reporting and compliance across all of AstraZeneca. Audit responsibility as the named control owner for software licence compliance, ensuring AstraZeneca is audit ready at all times, with risks tracked, communicated and managed. Lead vendor software licence audits (e.g. Microsoft, Oracle, SAP, IBM, Salesforce, Adobe, ServiceNow, VMware) and internal compliance assessments, owning remediation through to closure. Define and govern the end to end software lifecycle covering request, procurement, entitlement, deployment, usage, true up, reallocation and retirement, including the AZ Software Store experience. Value, Optimisation and FinOps Drive measurable cost optimisation and value realisation from AstraZeneca's strategic enterprise agreements, partnering with Procurement and Finance to inform renewals, true ups and rationalisation. Monitor and report consumption against entitlement, identifying gaps, surplus and reharvest opportunities, and feeding insight into the MTP and BTG investment cycles. Champion software economic decision making across BTGs and ETS, providing data led recommendations on standards, alternatives and consolidation. Tooling, data and integration Own the SAM tooling roadmap (Flexera FNMS, ServiceNow SAM, App Portal and adjacent capabilities), including vendor relationship management and customer success. Ensure integrity of SAM data - entitlements, contracts, installations and usage - and its integration with the CMDB and HAM as the single source of truth for software. Drive automation and self service in the software request, fulfilment and reclamation processes to improve customer experience and reduce manual effort. Stakeholder engagement and partnership Engages senior stakeholders across Procurement, Legal, Cyber Security, Enterprise Architecture, the BTGs and Finance to ensure SAM standards are effective and embedded. Manages strategic software publisher and SAM partner relationships to influence roadmaps, secure favourable commercial outcomes and unlock new capability for AstraZeneca. Promotes the advocacy for Software Asset Management and Software Licence Compliance across AstraZeneca, raising awareness and embedding the right behaviours. Leadership Lead and continuously develop a strong, globally distributed team across the UK and the Global Technology Centre (Chennai), building capability, succession and engagement. Be a key member of the WES - SACM Leadership Team ensuring the team continues to develop and grow and that strategies are aligned and executed effectively. Responsible for definition of successful business cases interlocking investment with the MTP to drive transformation of AstraZeneca's software governance capability. Education, Qualifications and Experience Essential Significant IT experience leading global Software Asset Management or comparable IT governance / compliance functions. Demonstrable track record of leading software vendor licence audits and large scale internal compliance programmes. Deep knowledge of enterprise software publishers and licence models - e.g. Microsoft, Oracle, SAP, IBM, Salesforce, Adobe, ServiceNow, VMware. Hands on experience of SAM tooling (Flexera FNMS, ServiceNow SAM, App Portal) and integration with ITSM and CMDB. Experience leading large global teams and multi million dollar software portfolios and budgets. Experience of dealing with Internal Audit, Risk and Compliance functions. Desirable Experience working in the Biopharmaceutical / Life Sciences industry. Recognised SAM / ITAM certifications - e.g. IAITAM CSAM, CITAM, ITIL, ISO/IEC 19770. Experience of FinOps / IT cost optimisation disciplines applied to software. Experience working across cultures and time zones, including a Global Technology Centre operating model. SDLC, Agile and Scrum methodologies. Next Steps Are you already imagining yourself joining our team? Good, because we can't wait to hear from you! Where can I find out more? Follow AstraZeneca on LinkedIn Follow AstraZeneca on Facebook Follow AstraZeneca on Instagram Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. Date Posted: 17-Jul-2026 Closing Date: 26-Jul-2026

AstraZeneca in Macclesfield invites applications for Director, ETS Software Asset Management. This role leads the global SAM capability, shaping strategy, policy, and process ownership across procurement, legal, cyber security and BTGs. You will ensure license compliance, audit readiness and maximum value from the software estate. Reporting to SACM leadership, the director will drive governance, tooling roadmap (Flexera FNMS, ServiceNow SAM), and a data-driven FinOps approach while leading a

AstraZeneca in London is seeking a proactive Business Unit Administrator - Oncology to support senior leadership and the Oncology Franchise with comprehensive administrative, operational, and project management tasks. Based on a fixed-term 12 month contract, the role focuses on diary management, governance, cross functional collaboration, and effective day to day functioning of the Oncology BU. On site, Mon-Fri, with strong organisational and confidentiality practices.

Business Unit Administrator - Oncology Business Unit: Oncology Reports to: Admin Manager Location: Pancras Square, London Working Pattern: On site (Monday-Friday) Contract Type: Fixed Term Contract Contract Duration: 12 months Join AstraZeneca in London - Supporting Science That Changes Lives AstraZeneca is a global, science led biopharmaceutical company focused on discovering, developing, and delivering life changing medicines for patients with serious diseases, including cancer. Our Oncology business plays a critical role in advancing innovative treatments, supported by strong operational and administrative excellence. We are now recruiting a Business Unit Administrator - Oncology to provide high level administrative, operational, and project management support to the Oncology Franchise, senior leadership and the wider team. This role is central to the effective day to day functioning of the Oncology Business Unit and requires strong organisational capability, discretion, and confidence working with Director level partners. Our Values - How We Work at AstraZeneca At AstraZeneca, our values guide how we work every day: Following the science to enable evidence based, compliant decision making Putting patients first by supporting teams that deliver medicines safely and effectively Doing the right thing through integrity, confidentiality, and accountability Playing to win by delivering high quality outcomes in a fast paced environment Being entrepreneurial by continuously improving systems, processes, and ways of working These values shape our culture and underpin how we collaborate across the organisation. The Role The Business Unit Administrator - Oncology provides comprehensive support to the Oncology Franchise Head/Business Unit Head and their wider teams, manages key franchise aligned activities, and delivers project management support for Oncology specific initiatives. This role sits within the Oncology Business Unit administration function and reports into the Senior PA/Admin Team leader. Key Accountabilities Individual Director Support to the Franchise/Department Heads. Provide proactive, high level administrative support to the Oncology Franchise or Business Unit Heads Manage complex and dynamic diaries to maximise efficiency and effective time management Prioritise and coordinate competing commitments, providing advance visibility of key activities Organise internal and external meetings, including room bookings, hospitality, and logistics Research, arrange, and manage travel and accommodation, producing detailed itineraries and proactively adjusting plans as diaries change Ensure all travel is approved in line with governance requirements Prepare and submit expenses, ensuring compliance with UKMC Travel & Expenses policy and highlighting any non compliance Raise priorities or issues appropriately in the absence of the Franchise or Business Unit Head Business Unit Support Coordinate wider Franchise or Business Unit Leadership Team meetings, including: Scheduling meetings Agenda creation with the rotating chair Liaising with presenters and collaborators Attending meetings and tracking actions Act as a key point of contact between the Franchise Head and Heads of Department Serve as a subject matter expert and first line support for systems such as: Cybergrants Concur Veeva Act as the single point of contact for new starters, supporting system access and onboarding training Provide expert support for virtual meetings and maintain up to date knowledge of collaboration tools and processes Create and maintain accurate BU distribution lists, organograms, and internal documentation Coordinate Franchise Team Meetings including offsite meetings, arranging venues, facilities, and logistics Any other admin related tasks required by the wider teams. Project Management Support, lead, and deliver projects as required by the Franchise. Project manage agreed initiatives from planning through to delivery Track progress against plan and communicate updates to interested parties Identify and implement opportunities to improve administrative systems and processes to enhance efficiency Admin Team Contribution Active member of the Oncology Business Unit admin team Share standard process and suggest improvements to ways of working Support or lead OBU wide or enterprise projects and events as required Experience, Skills & Qualifications Strong interpersonal, communication, and influencing skills Project coordination and delivery capability Flexible, positive, and proactive approach Ability to multitask within a fast paced environment. Self starter able to prioritise workload and work independently using sound judgement Ability to perform effectively under pressure High attention to detail and strong focus on quality Absolute discretion and ability to manage confidential and sensitive information Advanced verbal and written communication skills Advanced Microsoft Office skills Experience organising complex meetings and managing senior level diaries Demonstrated ability to make informed decisions when required Desirable Experience Proven experience providing administrative support at Director level Experience with governance processes and structured ways of working Strong business awareness and understanding of organisational priorities Career Development & Progression AstraZeneca offers a supportive and professional environment with clear development pathways. This role provides strong exposure to senior leadership and business operations, with potential future progression into advanced administrative, project coordination, or broader business support roles. Why AstraZeneca's 2 Pancras Square London Site? A flagship central London office with excellent national and international transport links Close proximity to UK and global Oncology leadership teams Strong cross functional collaboration in a modern, professional office environment A values driven culture focused on excellence, partnership, and impact Ready to Apply? If you are an experienced administrator with strong project coordination skills and enjoy supporting senior leaders in a dynamic environment, we would welcome your application. Date Posted 14-Jul-2026 Closing Date 25-Jul-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca GmbH in Macclesfield seeks a Cybersecurity Regulatory Compliance Manager to implement and lead compliance strategies across cybersecurity and business teams. This is an impactful role that aims to enhance AstraZeneca's cybersecurity posture globally while fostering regulatory compliance within a diverse and ambitious organization. The ideal candidate holds a BA/BSc degree in relevant fields, has expertise in security governance and regulations, and excels in communication and stakeholder management.

Director, Sustainability Macclesfield, UK (3 days on site per week) About AstraZeneca AstraZeneca is a global, science led, patient focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death. Come and join our AZ team where you will play a pivotal role in this exciting period of development The Director Sustainability leads a matrix team by fostering a collaborative, knowledge sharing environment, empowering team members, and driving accountability for sustainability initiatives. This role spearheads the Chemical Development sustainability initiative and actively collaborates to align with AstraZeneca's overall sustainability ambition. By leveraging the diverse expertise of the team and fostering cross functional cooperation, this leadership approach ensures agility, proactivity, and a steadfast commitment to achieving long term sustainable outcomes. Key Responsibilities: Strategic Leadership: Develop and lead the execution of a comprehensive sustainability strategy for the Chemical Development Department, ensuring alignment with broader corporate sustainability objectives and positioning the department as an industry leader in green chemistry. Provide strategic insights, data, and recommendations to senior leadership on sustainability matters, helping to influence decision making and future investments in sustainable development. Team Leadership: Guide cross functional teams, ensuring that sustainability principles are embedded in every stage of process development (from development through to commercialisation) and in department operations. Cultivate a culture of continuous improvement and innovation within the internal team. Advisory Role for External Partners: Serve as the key sustainability advisor for CDMO partners, driving the adoption of green chemistry, sustainable practices and carbon footprint reduction throughout the supply chain and manufacturing processes. Ensure that external partners share our sustainability goals and regulatory requirements. Sustainable Innovation: Through the team, identify and champion innovative technologies and processes that improve environmental sustainability, reduce waste, and minimise resource consumption. Ensure that innovations are aligned with long term business and environmental objectives. Regulatory and Compliance Oversight: Working with global SHE and ESM, ensure that all external partnerships align with relevant environmental regulations and sustainability standards. Work closely with regulatory teams to anticipate and adapt to evolving environmental policies. Collaboration and Influence: Build strong relationships with internal departments (R&D, Manufacturing, Supply Chain) and external stakeholders to ensure a seamless approach to sustainability across all operations. Promote internal awareness and engagement through education and advocacy at all levels. Requirements: A degree in chemistry, chemical engineering, pharmaceutical sciences, or a related subject area, alongside significant relevant experience in pharmaceutical, chemical, or manufacturing environments. Proven experience in developing and implementing sustainability strategies, ideally within chemical development, process chemistry, manufacturing, or supply chain operations. Detailed understanding of environmental compliance, sustainability standards, and evolving regulatory expectations relevant to the pharmaceutical sector. Excellent communication, stakeholder engagement, and influencing skills, including experience presenting recommendations to senior leadership. Significant experience working within a Research & Development or Manufacturing environments, within the pharmaceutical industry with comprehensive knowledge of development. Clear understanding of the full drug development pathway and how chemical development contributes to this. Strong technical expertise and understanding of practical synthetic organic chemistry and process development. Detailed understanding of the overall drug development process from discovery through to launch and lifecycle management. Strong external profile demonstrating scientific leadership. Extensive knowledge and experience of the subject areas within chemical development and how they combine to deliver commercial manufacturing processes and control strategies. In Office Requirement: When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life changing medicines. In person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Competitive salary and benefits package on offer! The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, a performance recognition scheme and a competitive, generous remuneration package. Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca Macclesfield seeks a Director of Sustainability to lead a matrix team and drive a comprehensive sustainability strategy for the Chemical Development Department, aligning with broader corporate goals. You will shape external partnerships, advance green chemistry, ensure regulatory compliance, and foster collaboration with R&D, Manufacturing, and Supply Chain to deliver sustainable outcomes.

AstraZeneca GmbH in Macclesfield is seeking a Senior Director of Artificial Intelligence and Data Strategy to lead digital transformation initiatives. This hybrid role requires strong leadership in AI integration within pharmaceutical operations, ensuring productivity and compliance. The ideal candidate will have a Master's degree in a relevant field, expertise in AI and data engineering, and a proven track record in strategic leadership and innovation. Join us to make a meaningful impact through cutting-edge science.

Job Title: Senior Director, Artificial Intelligence (AI) and Data Strategy, TOSI Reporting to: VP Technical Operations, Science & Innovation Location: Macclesfield, UK Hybrid working model - 3 days per week onsite At AstraZeneca, science compels us to push the boundaries of what is possible to turn science into life changing medicines for patients who need them most. We deliver breakthrough science by creating thriving, vibrant and open science centres where our scientists are free to pursue their ideas and collaborate both with colleagues and our academic and industry partners. Introduction to role: Are you ready to harness AI and data to reshape how life changing medicines are sustained at scale? In this role, you will set the vision and lead the execution of a bold AI and digital strategy that connects development to large scale technical operations, accelerating productivity, compliance, and problem solving across the commercial product lifecycle. You will lead a small, high performing team of AI and digital experts to deliver measurable impact-reducing cycle times, improving first time right outcomes, and embedding sophisticated analytics into daily decision making. If you can bring senior leaders together behind a clear and compelling roadmap, implement solutions that deliver lasting value, and build the capabilities that embed transformation for the long term, we would be delighted to hear from you. Accountabilities Vision and Strategy: Define and own the AI, data, and digital strategy for on market technical functions, aligned to business objectives and patient impact. Value Realisation: Drive measurable productivity gains and cost efficiencies; set benefit targets and ensure solutions translate to outcomes in the business. Portfolio Leadership: Build and manage a balanced portfolio of initiatives that redefine day to day operations, from pilot to scale. Indicators and Governance: Establish metrics, tracking mechanisms, and governance to ensure benefits are realised and sustained. Solution Delivery and Adoption: Lead the development, delivery, implementation, and adoption of digital and AI solutions that enhance efficiency and innovation across teams. Platform Integration: Partner with platform owners to integrate ERP, MES, QMS, and content/regulatory systems into end to end digital solutions. Data Architecture and Compliance: Shape robust data architectures and governance that enable AI at scale in regulated environments. Investment and Stakeholder Alignment: Create compelling business cases, align senior leaders, secure funding, and track the value delivered. Workforce Capability Uplift: Build a strategic capability programme that raises digital fluency and prepares the organisation for the future. Team Leadership: Lead and mentor a small team of AI/digital experts; foster a culture of innovation, delivery, and continuous improvement. Portfolio and Resource Management: Manage budgets, resources, and multi functional collaborations to meet commitments and influence outcomes. Safety, Quality and Standards: Champion SHE and cGMP principles while advancing digital transformation. Essential Skills/Experience Master's degree or equivalent experience or higher in a relevant science or engineering field. Technical expertise, including knowledge in the language of AI, data engineering, e.g., Python, R, cloud platforms (AWS/GCP). Solid understanding of data architecture, data governance, and AI deployment at scale in regulated environments. Experience working with enterprise platforms (e.g., ERP, MES, QMS, content/regulatory systems) and integrating them into digital solutions. Strong CMC knowledge with experience in Pharmaceutical Product Development and Manufacture, along with extensive knowledge of CMC processes across all product stages. Strategic leadership with a proven track record of developing, leading and delivering multi functional digital strategies and transformative programmes within a pharmaceutical CMC context. An innovative outlook that employs a digital first approach to streamline processes, enhance compliance, and foster efficiency. Outstanding business insight, proficiency in developing a strong argument for projects, organisational skills and lean tool deployment. Managing transitions and agility with ability to drive digital transformation and adapt strategy based on internal constraints or evolving tech/regulatory landscapes. Experienced in managing collaborators, good communication skills, capable of leading and collaborating effectively at senior levels. Ability to build consensus and navigate conflicts. A problem solving approach that delivers critical thinking and substantial business value. Thorough understanding of principles, applications and management of SHE and cGMP. Desirable Skills/Experience PhD or equivalent experience in a relevant scientific, engineering, or data field. Demonstrated experience operationalising MLOps, model lifecycle management, and validation in GxP contexts. Familiarity with generative AI, knowledge graphs, semantic layers, and digital twins for manufacturing and CMC. Experience leading global, multi functional teams and vendor ecosystems across multiple time zones. Knowledge of ICH guidelines (e.g., Q8-Q12) and regulatory interactions related to digital/AI enabled submissions. Track record of thought leadership (e.g., publications, conference talks, patents) on AI and data in CMC. Certification in Lean Six Sigma or portfolio/program management. Experience spanning both small molecule and biologics would be advantageous. Date Posted 25-Jun-2026 Closing Date 24-Jul-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.